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Posted by Tom Stork on October 14, 1999 at 07:30:22: In Reply to: Central Dogma & Inquiry posted by Andrea Anderson on October 10, 1999 at 18:07:07: As you might expect, I've faced the same problem in my sophomore class this year, Andrea. These were honors students, and my approach was not inquiry. I share you interest in increasing student discovery, though. I wonder if one might approach it from examination of diseases or conditions that occur because of single amino acid substitutions such as Sickle Cell disease? Perhaps locate articles that report the discovery of protein structure in Hemoglobin and others that describe linking genes to proteins and so forth. Maybe have the students try to piece together the central dogma from what's reported in these in these articles. In a sense, this is how Watson an Crick put together everyone else's research to explain DNA's structure and invent the dogma in the first place. Of course, all this presupposes pretty good reading and reasoning abilities.
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